Preterm birth is the single greatest cause of neonatal morbidity/mortality in the UK and occurs in approximately 7% of pregnancies. Symptomatic COVID-19 is associated with a 17% risk of primarily iatrogenic (94%) preterm birth, which is a two- to three-times greater risk compared with non-infected pregnant women (Allotey J et al 2020).
As well as preterm birth, COVID-19 infection is also associated with an increased risk of caesarean section (59%, with approxiamtely half of these owing to maternal or fetal compromise). Of these women, approximately one in five required general anaesthesia, two-thirds of these to intubate for maternal respiratory compromise.
Effect on the fetus
Aside from an increased likelihood of iatrogenic preterm birth, there is no evidence to date to implicate that COVID-19 has any adverse effects on the fetus or neonatal outcomes. Although symptomatic women are more likely to give birth before 32 and 37 weeks of gestation (adjusted odds ratio: 3.98 and 1.87, respectively).
Allotey J, Stallings E, Yap M, Chatterjee S, Kew, T, Debenham L et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ 2020;370:m3320